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KMID : 0371320020620020181
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Journal of the Korean Surgical Society
2002 Volume.62 No. 2 p.181 ~ p.186
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Vascular Diseases Associated with Protein C and/or S Deficiencies
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Cho Yong-Pil
Lee Deok-Hee
Jung Seung-Mun
Jang Hyuk-Jai
Kim Ji-Su
Han Myoung-Sik
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Abstract
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Purpose: There are a number of conditions that can lead to a
hypercoagulable state, however, protein C and S deficiencies are frequently
described as causes of the hypercoagulable states. The aim of this study was
to evaluate the clinical features and prognosis of vascular diseases
associated with protein C and/or S deficiencies and to determine an adequate
treatment modality for such cases. Methods: We prospectively
evaluated 7 cases with vascular disease caused by protein C and/or S
deficiencies confirmed with serologic tests. Results: Four patients
showed venous thrombosis, 1 peripheral arterial insufficiency, 1 cerebral
venous thrombosis and peripheral arterial insufficiency, and 1 portal vein
thrombosis. Surgical intervention was required in 5 patients. Full
anticoagulation with heparin sodium followed by warfarin sodium was done in
all patients. Conclusion: Protein C and S deficiencies may influence
clinical management. Patients presenting with atypical vascular involvement
without evidence of other risk factors should be evaluated for a
hypercoagulable state. Once the diagnosis is made, patients should be
treated with full anticoagulation.
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KEYWORD
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